Naturalproductman’s Blog

Hey, is that a natural product?!

Chemical Epigenetics

Posted by naturalproductman on May 8, 2010

Robert Cichewicz and co-workers at the University of Oklahoma have recently reported in the Journal of Natural Products on the isolation of a diverse group of structures from a fungus.  What’s interesting about this paper is that when the authors added 5-azacytidine, a DNA methyltransferase inhibitor, to this fungus (Penicillium citreonigrum), a different group of natural products were isolated.
epigenetics
JNP paper

5-azacytidine
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