Naturalproductman’s Blog

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Indene Synthesis

Posted by naturalproductman on May 20, 2010

Mark Lautens and co-worker at the University of Toronto have published in Organic Letters on the use of a gem-dibromoalkene to form an indene ring and a new C-C bond via an intermolecular Suzuki/Heck reaction.  Usually we see alkynes as precursors to these transition metal catalyzed indene formations, but this dibromo-olefin is another approach.

dibromo

OL paper

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