Naturalproductman’s Blog

Hey, is that a natural product?!

Apoptolidin G

Posted by naturalproductman on June 1, 2010

Bachmann, Sulikowski and co-workers at Vanderbilt have published in Organic Letters on the characterization of apoptolidin G.  Apoptolidin A had an EC50 of 50 nM against H292 cells while apoptolidin G had an EC50 of 150 nM.  The difference in the structures is the C2-C3 double bond geometry, which they have obtained via UV light irradiation of apoptolidin A.


OL paper


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: