Naturalproductman’s Blog

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Apoptolidin G

Posted by naturalproductman on June 1, 2010

Bachmann, Sulikowski and co-workers at Vanderbilt have published in Organic Letters on the characterization of apoptolidin G.  Apoptolidin A had an EC50 of 50 nM against H292 cells while apoptolidin G had an EC50 of 150 nM.  The difference in the structures is the C2-C3 double bond geometry, which they have obtained via UV light irradiation of apoptolidin A.

apoptolidin

OL paper

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