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Syntheses of Largazole and Analogs

Posted by naturalproductman on June 3, 2010

Angel de Lera and co-workers at Universidade de Vigo (Spain) have published in the Journal of Medicinal Chemistry on the syntheses of largazole and its analogs.  They further tested their HDAC inhibition.

JMC paper


One Response to “Syntheses of Largazole and Analogs”

  1. Susan Matthew said

    Please post the original article
    Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
    Taori K, Paul VJ, Luesch H. J Am Chem Soc. 2008 Feb 13;130(6):1806-7.

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