Naturalproductman’s Blog

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Synthesis of Goniomitine

Posted by naturalproductman on June 8, 2010

Jerome Waser and co-workers at Ecole Polytechnique Fédérale de Lausanne in Switzerland have published on a cyclopropane ring opening  strategy to synthesize goniomitine.  The strategy was to use a vinyl cyclopropyl ketone and open the cyclopropane with pTsOH to generate a precursor for a homo-Nazarov cyclization to access the six membered ring fused with the indole ring.

cyclopropane

ACIEE paper

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