Maria Valpuesta and co-workers from the Universidad de Malaga have published in the European Journal of Organic Chemistry on a Stevens rearrangement approach to synthesize substituted benzazepines.
Archive for July, 2010
Ring Expansion via Stevens Rearrangement
Posted by naturalproductman on July 31, 2010
Posted in Cascade Reactions, Methodology, Named Reactions, Ring expansion, Stevens rearrangement | Leave a Comment »
1,3-Dipolar Cycloaddition
Posted by naturalproductman on July 31, 2010
Mehdi Ghandi and co-workers at the University of Tehran have published in Tetrahedron on a 1,3-dipolar cycloaddition process between 3-acetyl coumarins and isatin. What’s interesting is the solvent determines if there is a deacetylation – in the case of methanol you lose the acyl group and in toluene, the acetyl remains in tact.
Posted in Cascade Reactions, Cycloaddition, Methodology, Pericyclic reactions, Spirocycles | Leave a Comment »
Oil Sponge
Posted by naturalproductman on July 29, 2010
George John and co-workers at CUNY are designing small molecules that will sequester oil from water.
Posted in Environmental, Methodology | Leave a Comment »
Baculiferins A-O
Posted by naturalproductman on July 27, 2010
Wenhan Lin and co-workers from Peking University have published on the isolation of some pyrrole alkaloids. Baculiferin M had an IC50 of 0.2 micrograms/mL against HIV-1 IIIB virus expressed in MAGI cells.
Posted in Alkaloids, Diseases, HIV | Leave a Comment »
Ugi then Staudinger-Aza-Wittig
Posted by naturalproductman on July 27, 2010
Tomas Torroba and co-workers from the Universidad de Burgos have published on an Ugi reaction followed by a Staudinger-Aza-Wittig cyclization. The key was that the carboxylic acid partner in the Ugi reaction was tethered by an azide group.
Posted in Aza-Wittig, Cascade Reactions, Methodology, Named Reactions, Staudinger, Ugi | Leave a Comment »