Naturalproductman’s Blog

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Huperine Skeleton

Posted by naturalproductman on August 17, 2010

Pierre-Yves Renard and co-workers at CNRS UMR have published in Tetrahedron on the synthesis of huperine skeleton via a Friedlander condensation using aluminum trichloride to generate a cyclohexanone from a mesylate in the presence of 2-amino-4-chlorobenzonitrile.

friedlander

Tetrahedron paper

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