Naturalproductman’s Blog

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Hyperibone Synthesis

Posted by naturalproductman on September 10, 2010

John Porco and co-workers at Boston University have published in JACS on the total synthesis of hyperibone.  They determined the absolute configuration by acylating a hydroxy group as the para-bromo benzoate ester to obtain an x-ray crystal structure.  The key step is the dearomatization/alkylation procedure using a cinchona alkaloid catalyst.

hyperibone

JACS paper

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