Naturalproductman’s Blog

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Synthesis of Caribenol A

Posted by naturalproductman on September 10, 2010

Zhen Yang and co-workers at Peking University have published in JACS on the total synthesis of caribenol via an intramolecular Diels-Alder reaction using an activated alkyne as the dienophile.  The intramolecular Diels-Alder reaction required the use of a catalytic amount of 2,6-di-tert-butyl-4-methylphenol (BHT) – an antioxidant.

Diels Alder

JACS paper

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