Naturalproductman’s Blog

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Exocyclic Methylenes

Posted by naturalproductman on November 28, 2010

Tomasz Janecki and co-workers have published in Synlett on a nice way to make subsituted 3-methylidene-chroman-2-ones (ie:  exocyclic methylenes) via 1,4-Grignard addition folowed by Wittig.

exocyclic methylene

Synlett paper

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