Naturalproductman’s Blog

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Spirocurcasone

Posted by naturalproductman on December 9, 2010

Orazio Taglialatela-Scafati and co-workers at Universita di Napoli have published in Organic Letters on the isolation of some diterpenoids including a novel spirocycle, spirocurcasone, however, this new spirocyclic compound did not seem to have any biological activity.  A related structure, curcasone C, had an IC50 value of 0.08 micrograms/mL against the L5178Y (mouse lymphoma) cell line.

spirocurcasone

 

OL paper

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