Naturalproductman’s Blog

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Isomerization with Lawesson’s Reagent

Posted by naturalproductman on December 20, 2010

Lawesson’s reagent normally converts carbonyls to thiocarbonyls.  Emanuele Miserazzi and co-workers at GlaxoSmithKline in Italy have published in Tetrahedron Letters on a transposition of the oxidized atom in N-benzylpiperazinones when using Lawesson’s reagent.

transposition

 

TL paper

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