Naturalproductman’s Blog

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Multi-Component Cascade

Posted by naturalproductman on January 21, 2011

Xian Huang and co-workers from Zhejiang University have published in Organic Letters on a multi-component coupling approach that takes advantage of an interesting way to form a phosphorous ylide – by addition of an alkyl lithium onto an alkynyl phosphine oxide.

phosphine

 

JOC paper

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