Naturalproductman’s Blog

Hey, is that a natural product?!

Inactive Analog

Posted by naturalproductman on January 24, 2011

Piet Herdewijn and co-worker at the Katholieke Universiteit Leuven in Belgium have reported on a nucleoside analog in the hopes of uncovering anti-HCV activity.  Unfortunately however, this compound did not have any biological activity.  You might think that this information is not good because it didn’t have biological activity – but to a computational chemist, who is familiar with QSAR (quantitative structure activity relationships) and COMFA, COMSIA and other computer aided drug design techniques, this information is indeed valuable.  The paper does mention however a biologically active  nucleoside analog (a natural product), C-branched nucleoside oxetanocin A, that has a four membered ring instead of the usual ribose ring.

anti HCV

European JOC paper

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