Naturalproductman’s Blog

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Nobiletin Studies

Posted by naturalproductman on January 24, 2011

Toshiyuki Kan and co-workers at the University of Shizuoka and Global COE program have reported in Chem Comm on a total synthesis of nobiletin where they incorporated a 11C isotope to visualize the compound through PET (positron emission tomography) in order to see where it goes in the rat brain.  Nobiletin was found to enhance PKA/ERK/CREB signalling in rat hippocampal neurons.

nobiletin

Chem Comm paper

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