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Nobiletin Studies

Posted by naturalproductman on January 24, 2011

Toshiyuki Kan and co-workers at the University of Shizuoka and Global COE program have reported in Chem Comm on a total synthesis of nobiletin where they incorporated a 11C isotope to visualize the compound through PET (positron emission tomography) in order to see where it goes in the rat brain. Nobiletin was found to enhance PKA/ERK/CREB signalling in rat hippocampal neurons.

nobiletin

Chem Comm paper

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This entry was posted on January 24, 2011 at 12:59 pm and is filed under Alzheimer's, Aromatic, Diseases, Methodology, Total Synthesis. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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