Naturalproductman’s Blog

Hey, is that a natural product?!

Dimethylsulfonium Methylide Cascade

Posted by naturalproductman on February 12, 2011

If I were to tell you a dimethylsulfonium methylide were used as the reagent – you’d probably predict it to be a Corey-Chaykovsky reaction.  However, in this case reported by Philip Fuchs and colleague at Purdue, it is an SN2 prime addition followed by an elimination of dimethyl sulfide.

dimethyl sulfide

Chem Comm paper

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

 
%d bloggers like this: