Naturalproductman’s Blog

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Dimethylsulfonium Methylide Cascade

Posted by naturalproductman on February 12, 2011

If I were to tell you a dimethylsulfonium methylide were used as the reagent – you’d probably predict it to be a Corey-Chaykovsky reaction.  However, in this case reported by Philip Fuchs and colleague at Purdue, it is an SN2 prime addition followed by an elimination of dimethyl sulfide.

dimethyl sulfide

Chem Comm paper


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