Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for July, 2011

Streptolydigin activities

Posted by naturalproductman on July 25, 2011

Sergey Kozmin and co-workers from the University of Chicago have reported in JACS on their streptolydigin syntheses and antibacterial activity.

antibacterial

JACS paper

Posted in Antibiotics, Methodology, Polyenes | Leave a Comment »

Cortistatin J synthesis

Posted by naturalproductman on July 25, 2011

Raymond Funk and colleague at Penn State have reported in JACS on a synthesis of cortistatin J with one of the key reactions being a [4+3] intramolecular cycloaddition.

cortistatin J

JACS paper

Posted in Alkaloids, Cycloaddition, Methodology, Organocatalytic, Pericyclic reactions, Total Synthesis | Leave a Comment »

Trigonoliimines A-C syntheses

Posted by naturalproductman on July 12, 2011

Mohammad Movassaghi and colleague have reported in JACS on the total synthesis of trigonoliimines A-C.

asd

JACS paper

Posted in Alkaloids, Indoles, Methodology, Total Synthesis | 2 Comments »

Alkaloid syntheses

Posted by naturalproductman on July 12, 2011

Chun-An Fan and co-workers have reported in ACIEE on their syntheses of some alkaloids using organocatalytic Michael addition.

organocatalytic

ACIEE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Michael, Named Reactions, Organocatalytic | Leave a Comment »

Huperzine Q synthesis

Posted by naturalproductman on July 12, 2011

Hiromitsu Takayama and co-workers at Chiba University have reported in ACIEE on their synthesis of huperzine Q featuring a Pauson-Khand reaction to introduce the cyclopentenone.

huperzine

ACIEE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Named Reactions, Pauson-Khand, Ring forming, Total Synthesis | Leave a Comment »

Gliocladin C synthesis

Posted by naturalproductman on July 12, 2011

Corey Stephenson and co-workers at Boston University have reported in ACIEE on their synthesis of gliocladin C.

gliocladin C

ACIEE paper

Posted in Alkaloids, Cascade Reactions, Light Mediated, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

Polychlorinated natural product

Posted by naturalproductman on July 12, 2011

Erick Carreira and co-workers have reported in ACIEE on their synthesis of this lipid that contains eleven chlorines.

chlorosulfolipid

ACIEE paper

Posted in Julia-Kocienski, Martin sulfurane, Methodology, Named Reactions, Named Reagents | Leave a Comment »

Characterization of starches

Posted by naturalproductman on July 11, 2011

Robert Gilbert and co-workers from the University of Queensland have reported in JAFC on the use of deuterated trifluoroacetic acid to measure degree of branching in starches.

deuteration

JACF paper

Posted in Methodology | Leave a Comment »

Alkyl zinc addition onto alkene

Posted by naturalproductman on July 11, 2011

Matthew Sigman and colleague at the University of Utah have reported in JACS on an anti-Markovnikov addition of an alkyl group onto an alkene using an alkyl zinc reagent.

zinc

JACS paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal, Zinc | Leave a Comment »

Allenoate cycloaddition

Posted by naturalproductman on July 11, 2011

Xiyan Lu and co-workers from the Shanghai Institute of Organic Chemistry have reported in JOC on an allenoate cycloaddition using a palladium catalyst.

allenoate

JOC paper

Posted in Allenes, Cascade Reactions, Cycloaddition, Methodology, Palladium, Pericyclic reactions, Transition Metal | Leave a Comment »