Naturalproductman’s Blog

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MCC with benzynes

Posted by naturalproductman on September 24, 2011

Hiroto Yoshida and co-workers at Hiroshima University have reported in ACIEE on a three component coupling between a benzyne, aryl or alkynyl bromide and nucleophile to form substituted aryl bromides.  What’s fascinating is that the aryl or alkynyl group transfers to the nucleophile.

benzyne

ACIEE paper

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