Naturalproductman’s Blog

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Kynurenine is a ligand for the AH receptor

Posted by naturalproductman on October 11, 2011

Michael Platten and co-workers from the German Cancer Research Center have reported in Nature on the role of kynurenine (Kyn), which is the TDO (tryptophan-2,3-dioxygenase) enzyme product of tryptophan. They report that Kyn is an endogenous ligand for the aryl hydrocarbon receptor, which is a transcription factor with a very complex story behind it.


Nature paper


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