Naturalproductman’s Blog

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NP25302 synthesis

Posted by naturalproductman on October 19, 2011

Jeremy Robertson and co-workers at the University of Oxford have reported in Organic Letters on the synthesis of NP25302 taking advantage of a TMSOTf mediated 5-endo-dig cyclization followed by a Curtius rearrangement to form the Csp2-nitrogen bond.

NP25302

OL paper

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