Mary Fletcher and co-workers from the University of Queensland have reported in the Journal of Agricultural and Food Chemistry on the isolation of cromedine from a plant, crotalaria medicaginea, that has been thought to be the reason for horse deaths in Australia.
Archive for October, 2011
What’s killing the horses?
Posted by naturalproductman on October 23, 2011
Posted in Alkaloids | Leave a Comment »
NHC catalysis
Posted by naturalproductman on October 23, 2011
David Lupton and co-worker from Monash University have reported in Chemical Science on a carbene catalyzed cyclopropane-rearranging/C-C bond forming cascade.
Posted in Carbene, Cascade Reactions, Methodology, Ring Opening | Leave a Comment »
Racemization with DFT
Posted by naturalproductman on October 23, 2011
Filip Teply and co-workers have published in Chemical Science on the use of DFT ((TURBOMOLE, B3LYP) to observe the racemization pathway of a molecule.
Posted in Computational, DFT | Leave a Comment »
Transannular Claisen rearrangement
Posted by naturalproductman on October 23, 2011
Donald Craig and co-workers at Imperial College have reported in Organic and Biomolecular Chemistry on a transannular Claisen rearrangement converting a lactone into a cyclobutane.
Posted in Claisen rearrangement, Methodology, Named Reactions, Ring contraction | Leave a Comment »
Alpha-chloro group slows enamine formation
Posted by naturalproductman on October 20, 2011
Keiji Maruoka and co-workers at Kyoto University have reported in JACS on a cross-Aldol coupling between two distinct aldehydes, one with an alpha-chloro group. It turns out that the chloride group slows down the enamine formation.
Posted in Aldol, Asymmetric, Methodology, Named Reactions, Organocatalytic | Leave a Comment »
Complestatin A an B syntheses
Posted by naturalproductman on October 20, 2011
Dale Boger and colleague have reported in JACS on their synthesis of complestatin A and B.
Posted in Methodology, Peptides, Total Synthesis | Leave a Comment »