Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for November, 2011

Piperidines via N-debenzylation

Posted by naturalproductman on November 21, 2011

Stephen Davies and co-workers at Oxford have reported in Tetrahedron on the synthesis of piperidines by an N-debenzylation process.

piperidine

Tetrahedron paper

Posted in Asymmetric, Cascade Reactions, Methodology | Leave a Comment »

Tormesol via Wittig

Posted by naturalproductman on November 21, 2011

Dongjoo Lee and co-workers at Dankook University have reported in Tetrahedron on the synthesis of tormesol.  The seven membered ring was acquired from a Horner-Wadsworth-Emmons reaction.

Wittig

Tetrahedron paper

Posted in Horner-Wadsworth-Emmons, Methodology, Named Reactions, Named Reagents, Sesquiterpenoids, Total Synthesis, Wittig | Leave a Comment »

Transannular Michael

Posted by naturalproductman on November 21, 2011

Gerald Pattenden and colleague at the University of Nottingham have reported in Tetrahedron on the synthesis of ineleganolide via a Michael reaction.

synthesis
Tetrahedron paper

Posted in Cascade Reactions, Methodology, Michael, Named Reactions, Ring forming, Transannular | Leave a Comment »

Eight membered ring from four membered ring

Posted by naturalproductman on November 21, 2011

Rick Danheiser and co-workers at MIT have reported in Tetrahedron on a way to make cyclo-octatrienes.

cyclooctatriene

Tetrahedron paper

Posted in Allenes, Electrocyclization, Methodology, Pericyclic reactions | Leave a Comment »

Saudin synthesis

Posted by naturalproductman on November 21, 2011

Robert Boeckman and co-workers at the University of Rochester have reported in Tetrahedron on the synthesis of saudin.

saudin

Tetrahedron paper

Posted in Asymmetric, Cascade Reactions, Claisen rearrangement, Methodology, Named Reactions, Terpenes | Leave a Comment »

Demethylwyosine biosynthesis

Posted by naturalproductman on November 19, 2011

Vahe Bandarian and colleague at the University of Arizona have reported in Biochemistry on the biosynthetic study of demethylwyosine.

demethylwyosine

Biochemistry paper

Posted in Biosynthesis, Chemical Biology, Nucleic acids | Leave a Comment »

Virginiamycin M2 synthesis

Posted by naturalproductman on November 19, 2011

James Panek and colleague at Boston University have reported in JOC on the synthesis of virginiamycin M2.

virginiamycin

JOC paper

Posted in Asymmetric, Copper, Macrolides, Methodology, Rhodium, Transition Metal | Leave a Comment »

Theaflavins for Alzheimer’s and Parkinson’s

Posted by naturalproductman on November 19, 2011

Jan Bieschke and co-workers at Washington University in St. Louis have reported in Biochemistry on the inhibition of theaflavins as inhibitors of amyloid-beta and alpha-synuclein fibrillogenesis.

theaflavins

Biochemistry paper

Posted in Alzheimer's, Aromatic, Diseases, Flavins, Parkinson's, Polyphenolic | Leave a Comment »

Polygalolide A synthesis

Posted by naturalproductman on November 17, 2011

Masaatsu Adachi and co-workers from Nagoya have reported in Organic Lettes on the synthesis of polygalolide A.

polygalolide A

OL paper

Posted in Asymmetric, Cascade Reactions, Methodology, Spirocyclic centers | Leave a Comment »

Burkholdac B synthesis

Posted by naturalproductman on November 17, 2011

Ganesan and co-workers at the University of Southampton have reported in Organic Letters on a synthesis of burkholdac B, which has an IC50 of 60 pM against MCF7 breast cancer cell lines.

burkholdac B

OL paper

Posted in breast, Cancer, Methodology, Peptides, Total Synthesis | Leave a Comment »