Naturalproductman’s Blog

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Trifluoromethylation with hypervalent iodide

Posted by naturalproductman on February 20, 2012

Zhiqiang Weng and co-workers from Fuzhou University have reported in Tetrahedron on the use of a hypervalent iodide to introduce a trifluoromethyl group on the terminal position of an alkyne.

hypervalent iodide

Tetrahedron paper


2 Responses to “Trifluoromethylation with hypervalent iodide”

  1. Dr Jim Romano said

    A much easier way is through TMSCF3….CuI, KF…yield I think was very high !!!!

    • Johnny Bravo said

      The method with TMSCF3 requires slow addition of the TMSCF3 while sparging with O2, I believe. It’s an interesting reaction, but I would say it’s not as operationally simple as Weng’s reaction.

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