Click cascade
Posted by naturalproductman on February 23, 2012
Qian Cai and co-workers from Guanzhou Institutes of Biomedicine and Health have reported in Organic Letters on a click reaction followed by cross coupling.
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Posted by naturalproductman on February 23, 2012
Qian Cai and co-workers from Guanzhou Institutes of Biomedicine and Health have reported in Organic Letters on a click reaction followed by cross coupling.
milkshake said
Copper azide is notoriously treacherous – lead azide primers must be kept apart from copper-based alloys so that they do not become unstable. In this case they use high copper loading, they mix the stuff up with inorganic azide without much info about the addition order and the mix heat up to 90C. I am afraid someone will get hurt by trying this on gram scale. (They could have started at room temp and gradually heat the mixture. They could have made observations about precipitate formation, if they tried to be responsible, etc). Here is another blatantly dangerous system – iodine + ammonia mixed together and then heated in a pressure vessel: http://pubs.acs.org/doi/abs/10.1021/ol901250c
naturalproductman said
Wow – that is indeed scary especially because they made that (CuN3) in situ. Safety should be top priority when running reactions not just coming up with some crazy cool idea. Thanks for the heads up.