Naturalproductman’s Blog

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Archive for February, 2012

Caloundrin B synthesis

Posted by naturalproductman on February 29, 2012

Dale Ward and colleague at the University of Sasketchewan have reported in Organic Letters on the synthesis of

caloundrin B

OL paper

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Posted in Cascade Reactions, Methodology, Polyketides, Spiroketals | Leave a Comment »

Thiophene and alkene

Posted by naturalproductman on February 29, 2012

Takeshi Ohkuma and co-workers at Hokkaido University have reported in Organic Letters on a light mediated intramolecular cyclization of a thiophene and an alkene.

cyclization

OL paper

Posted in Cascade Reactions, Light Mediated, Methodology, [2+2] | Leave a Comment »

Frondosin via Paterno Buchi

Posted by naturalproductman on February 29, 2012

Jonathan George and co-workers at the University of Adelaide have reported in Organic Letters on a Paterno Buchi reaction approach to access the 5 membered ring of frondosin.

Paterno Buchi

OL paper

Posted in Alkaloids, Cycloaddition, Light Mediated, Methodology, Named Reactions, Paterno-Buchi, Pericyclic reactions, [2+2] | Leave a Comment »

Uh oh beer and cancer?

Posted by naturalproductman on February 25, 2012

Veronika Somoza and co-workers from the University of Vienna have reported in the Journal of Agricultural and Food Chemistry on the report that beer stimulated the formation of gastric acids in the stomach.

 

JAFC paper

Posted in Cancer, stomach | Leave a Comment »

Oxysulfenylation

Posted by naturalproductman on February 24, 2012

Yian Shi and co-workers have reported in Tetrahedron on oxysulfenylation oxyselenylation processes using a Bronstead acid.

oxysulfenylation

Tetrahedron paper

Posted in Asymmetric, Cascade Reactions, Methodology | Leave a Comment »

Click cascade

Posted by naturalproductman on February 23, 2012

Qian Cai and co-workers from Guanzhou Institutes of Biomedicine and Health have reported in Organic Letters on a click reaction followed by cross coupling.

click

OL paper

Posted in Cascade Reactions, Copper, cross coupling, Methodology, Transition Metal | 2 Comments »

Substituted THPs from cascade

Posted by naturalproductman on February 23, 2012

Aurelio Csaky and co-workers from Universidad have reported in Organic Letters on an interesting way to form substituted tetrahydropyran rings.

THP

OL paper

Posted in Cascade Reactions, Methodology, Michael, Named Reactions | Leave a Comment »

Mucosin synthesis

Posted by naturalproductman on February 23, 2012

Richard Whitby and co-workers from the University of Southampton have reported in Chemical Communications on the synthesis of mucosin via a zirconium catalyzed cyclization, which reminded me of the kind that Negishi had published before.

zirconium

Chemical Communications paper

Posted in Cascade Reactions, Methodology, Ring forming, Total Synthesis, Transition Metal, Zirconium | Leave a Comment »

Aromatic trifluoromethylation

Posted by naturalproductman on February 23, 2012

Stefan Brase and colleague from the Institute of Organic Chemistry in Germany have reported in ACIEE on a trifluoromethylation of an aromatic triazene via AgCF3 formed in situ.

aryl

ACIEE paper

Posted in Cascade Reactions, Fluorine, Methodology, Silver, Transition Metal | Leave a Comment »

Tripartilactam

Posted by naturalproductman on February 23, 2012

Dong-Chan Oh and co-workers from Seoul National University have reported in Organic Letters on the isolation of tripartilactam from a bacteria found in a dung beetle’s brood ball.

tripartilactam

OL paper

Posted in Cyclobutanes, Lactams | Leave a Comment »