Naturalproductman’s Blog

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Fluorous mixture synthesis application

Posted by naturalproductman on May 1, 2012

Dennis Curran and co-workers at the University of Pittsburgh have applied fluorous mixture synthesis to assign the stereochemistry of a macrolide.  Fluorous mixture synthesis is a technique where they install fluorinated tag protecting groups on the alcohols where each tag varies by the number of fluorines.  They are able to separate the tagged compounds based on the number of flourines on the tags.

fluorous

JACS paper

Science paper

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