Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for May, 2012

Halichoblelides B and C

Posted by naturalproductman on May 2, 2012

Takeshi Yamada and co-workers at Osaka University of Pharmaceutical Sciences have reported in Tetrahedron on the isolation of some cytotoxic natural products, halichoblelides B and C.

anti cancer

TL paper

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Posted in Cancer, colon, leukemia, Macrolides | Leave a Comment »

Furan ring opening

Posted by naturalproductman on May 2, 2012

Alexander Butin and co-workers at  Kuban State Technological University in the Russian Federation have reported in Tetrahedron on a tin mediated furan ring opening reaction.

furan

Tetrahedron paper

Posted in Cascade Reactions, Methodology, Ring Opening | Leave a Comment »

Chemists helping chemists

Posted by naturalproductman on May 2, 2012

It’s always nice to have a helpful website on lab techniques and such:  chemtips, justlikecooking, orgprepdaily, corante, syntheticnature, heterocyclist, joshphd, organometallics, chemicalblogspace

Posted in Links, Random | Leave a Comment »

Anominine and tubingensin A synthesis

Posted by naturalproductman on May 2, 2012

Ang Li and co-workers at Shanghai Institute of Organic Chemistry have reported in JACS on a synthesis of anominine and tubingensin A.
tubingensin

JACS paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Fluorous mixture synthesis application

Posted by naturalproductman on May 1, 2012

Dennis Curran and co-workers at the University of Pittsburgh have applied fluorous mixture synthesis to assign the stereochemistry of a macrolide.  Fluorous mixture synthesis is a technique where they install fluorinated tag protecting groups on the alcohols where each tag varies by the number of fluorines.  They are able to separate the tagged compounds based on the number of flourines on the tags.

fluorous

JACS paper

Science paper

Posted in Macrolides, Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »