Naturalproductman’s Blog

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Silver catalyzed decarboxylative fluorination

Posted by naturalproductman on June 14, 2012

Chaozhong Li and co-workers at Shanghai Institute of Organic Chemistry have reported in JACS on a silver catalyzed decarboxylative fluorination.

decarboxylative fluorination

JACS paper

3 Responses to “Silver catalyzed decarboxylative fluorination”

  1. milkshake said

    I was making 2-fluoro-bromofuran from bromofuroic acid, for fluorofuryl lithium generation. The bromofuroic acid decarboxylative fluorination worked even without silver (0C, water/pentane, bicarbonate, Selectfluor). The yield was poor but the obtained fluorobromofuran was very pure

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