Naturalproductman’s Blog

Hey, is that a natural product?!

Another Nazarov? Or not.

Posted by naturalproductman on August 31, 2012

Zhang-Jie Shi and co-workers at Peking University have reported in Organic Letters on a palladium catalyzed cyclization process, which at first glance looked like it may be a Nazarov reaction but they proved that it probably is not a Nazarov reaction because of the observed kinetic isotope effect when they replaced the aryl hydrogens with deuteriums.

no not a Nazarov

OL paper

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