Naturalproductman’s Blog

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Chlorizidine A

Posted by naturalproductman on February 20, 2013

Chambers Hughes and co-workers at Scripps have reported in Organic Letters on the isolation of chlorizidine A, which had low micromolar LC50 values against some cancer cell lines from NCI. Another interesting point in this paper is the way they assigned the chiral carbon stereocenter as S from an X-ray crystal structure of the molecule, which also incorporated a benzene molecule. They determined the stereocenter using the Flack parameter.

chlorizidine A

OL paper

Flack parameter ref (Acta Cryst)

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