Naturalproductman’s Blog

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Archive for March, 2013

Iron catalyzed [2+2]

Posted by naturalproductman on March 15, 2013

Paul Chirik and co-workers from Princeton have reported in JACS on a mechanistic study of an iron catalyzed [2+2].

iron

JACS paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Rh-cascade

Posted by naturalproductman on March 15, 2013

Richmond Sarpong and colleague have reported in JACS on a synthesis of a cycloprodigiosin.

rhodium

JACS paper

Posted in Cascade Reactions, Methodology, Rhodium, Transition Metal | Leave a Comment »

ATR-FTIR-UV/Vis monitoring of a reaction

Posted by naturalproductman on March 13, 2013

Ursula Bentrup and co-workers at Universitat Rostock in Germany have reported in Tetrahedron on an interesting setup to monitor a reaction.

monitor

Tetrahedron paper

Posted in Mechanistic, Methodology, New Setups, Titanium, Transition Metal | Leave a Comment »

Kinetic resolution with phosphoric acid

Posted by naturalproductman on March 13, 2013

William Roush and co-workers have reported in Org Lett on a kinetic resolution using phosphoric acid.

kinetic resolution

OL paper

Posted in C2-Symmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Pd-catalyzed 3 component coupling

Posted by naturalproductman on March 13, 2013

Matthew Sigman and colleague at the University of Utah have reported in JACS on a palladium catalyzed three component coupling reaction.

three

JACS paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Palladium, Transition Metal | Leave a Comment »

Ca-catalyzed cyclopropanation

Posted by naturalproductman on March 8, 2013

Meike Niggemann and co-workers at RWTH Aachen University have reported in ACIE on a calcium catalyzed cyclopropanation reaction.

cyclopropanation

ACIE paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Spongiastatin 2 synthesis

Posted by naturalproductman on March 8, 2013

Steven Ley and co-workers have reported in Chemical Science on the synthesis of spongiastatin 2.

spongiastatin 2

Chemical Science paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Mitsunobu with a catalytic twist

Posted by naturalproductman on March 8, 2013

Hiroyuki Ishibashi and co-workers at Kanazawa University have reported in ACIE on a Mitsunobu reaction where they use an iron catalyst and oxygen to regenerate the active azo reagent.

azo

ACIE paper

Posted in Catalytic, Iron, Methodology, Mitsunobu, Named Reactions, Transition Metal | Leave a Comment »

Kingianin synthesis

Posted by naturalproductman on March 6, 2013

Michael Sherburn and co-workers from Australian National University have reported in ACIE on the synthesis of kingianins A, D, and F from a poly-yne precursor.  Ledwith-Weitz salt was used to promote a Diels-Alder dimerization.

Diels-Alder

 

ACIE paper

Posted in Cascade Reactions, Diels-Alder, Ledwith-Weitz salt, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

What makes beer bitter…

Posted by naturalproductman on March 6, 2013

Werner Kaminsky and co-workers from the University of Washington have reported in ACIE on the isolation of humulone.

beer

ACIE paper

Posted in Tetrahydro-iso-alpha-acids | Leave a Comment »