Naturalproductman’s Blog

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Archive for April, 2013

Anti-Markovnikov oxidation of allylic esters

Posted by naturalproductman on April 18, 2013

Ben Feringa and co-workers at the University of Groningen have reported in ACIE on a palladium catalzyed anti-Markovnikov oxidation of allylic esters.  This is the opposite of what we see in a Wacker-Tsuji process.

palladium
ACIE paper

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Posted in Methodology, Named Reactions, Palladium, Transition Metal, Wacker | Leave a Comment »

Linoxepin synthesis

Posted by naturalproductman on April 18, 2013

Mark Lautens and co-workers at the University of Toronto have reported in ACIE on the synthesis of linoxepin.

linoxepin

ACIE paper

Posted in Aromatic, Polyketides, Total Synthesis | Leave a Comment »

Epoxyisoprostane synthesis

Posted by naturalproductman on April 18, 2013

Erick Carreira and co-workers have reported in ACIE on the synthesis of some pro-inflammatory compounds, which look like good Michael acceptors.

epoxyisoprostane

ACIE paper

Posted in Biological activity, Total Synthesis | Leave a Comment »

Maltepolide A

Posted by naturalproductman on April 18, 2013

Evygeny Prusov and co-workers have reported in ACIE on the isolation and biological activity of maltepolide A.

maltepolide A

ACIE paper

Posted in Biological activity, Macrolides | Leave a Comment »

19-Hydroxysarmentogenin synthesis

Posted by naturalproductman on April 18, 2013

Masayuki Inoue and co-workers from University of Tokyo have reported in ACIE on a synthesis of 19-hydroxysarmentogenin.

steroid

ACIE paper

Posted in Methodology, Steroids, Total Synthesis | Leave a Comment »

Englerin A synthesis

Posted by naturalproductman on April 18, 2013

Peter Metz and co-workers at Technische Universität Dresden have reported in ACIE on a synthesis of englerin A.

englerin A

ACIE paper

Posted in Methodology, Sesterterpenoids, Total Synthesis | Leave a Comment »

Pactamycin synthesis

Posted by naturalproductman on April 12, 2013

Jeffrey Johnson and co-workers at UNC have reported in Science on the synthesis of pactamycin.

 

Science paper

Posted in Antibiotics, Total Synthesis | Leave a Comment »

Fluoronium ion

Posted by naturalproductman on April 5, 2013

Thomas Lectka and co-workers at Johns Hopkins University have reported in Science on some evidence of a fluoronium ion.

 

Science paper

Posted in Methodology | Leave a Comment »

Bcl-XL and Bcl-2 interaction

Posted by naturalproductman on April 5, 2013

Thorsten Berg and co-workers at the University of Leipzig have reported in ACIE on the study of some small molecules disrupting the interaction of Bcl-XL and Bcl-2.

apoptosis

ACIE paper

Posted in Protein Targets, Proteins, Receptors | Leave a Comment »

Asymmetric acetalization

Posted by naturalproductman on April 5, 2013

Benjamin List and co-workers published in ACIE on an enantioselective acetalization.

acetalization

ACIE paper

Posted in Asymmetric, Methodology | Leave a Comment »