Naturalproductman’s Blog

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Archive for May, 2013

Epoxide opening cascade

Posted by naturalproductman on May 31, 2013

Yoshiki Morimoto and co-workers at Osaka City University have reported in Organic Letters on a polyepoxide ring opening reaction.

epoxide

OL paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

TMS diazomethane: a new use

Posted by naturalproductman on May 30, 2013

Daesung Lee and co-workers from UIC have reported in Org Lett on the use of a trimethylsilyldiazomethane reaction. This reagent is usually used to form alkynes from aldehydes.

trimethylsilyldiazomethane

OL paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Gelsemoxonine synthesis

Posted by naturalproductman on May 30, 2013

Erick Carreira and colleague have reported in JACS on a synthesis of gelsemoxonine.

gelsemoxonine

JACS paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Dual catalysis

Posted by naturalproductman on May 30, 2013

Erick Carreira and co-workers have published in Science on a cooperative catalysis reaction that forms a quaternary carbon center.

 

Science paper

Posted in Asymmetric, Diastereoselective, Methodology | Leave a Comment »

Diyne desymmetrization

Posted by naturalproductman on May 21, 2013

Ulrich Hennecke and co-workers at the Universitat Munster have reported in JAC on a desymmetrization of a diyne.

Diyne

JACS paper

Posted in Alkaloids, Asymmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Desymmetrizing oxetanes

Posted by naturalproductman on May 21, 2013

Jianwei Sun and co-workers from the Hong Kong University of Science and Technology have reported in ACIE on a desymmetrization of oxetanes using a phosphoric acid catalyst.

desymmetrization

ACIE paper

Posted in Asymmetric, Desymmetrization, Methodology | Leave a Comment »

Roxbin B

Posted by naturalproductman on May 21, 2013

Hidetoshi Yamada and co-workers at Kwansei Gakuin University have reported in JOC on a structural reassignment concluding that roxbin B is cuspinin.

roxbin B

JOC paper

Posted in Glycosides, Methodology, Structural Reassignment, Total Synthesis | Leave a Comment »

Long C-O bond

Posted by naturalproductman on May 21, 2013

Mark Mascal and co-workers at UC Davis have published in JACS on a long C-O bond in an oxonium ion.

ion

JACS paper

Posted in Methodology | Leave a Comment »

Spectral Database for Instructors

Posted by naturalproductman on May 20, 2013

Andrew Harned’s group in Minnesota has put up a site on spectral database for instructors. It would be useful for any chemist if they wanted to find the FID for any NMR spectrum of a compound they are trying to make.  I think this would be actually a good idea to have for any compound in general as proof of compound synthesized.  It would be nice if we don’t have to be instructors to use it though.

JCE paper

Posted in Random | Leave a Comment »

Dictyostatin synthesis

Posted by naturalproductman on May 17, 2013

James Leighton and co-workers have reported in ACIE on the synthesis of dictyostatin.

dictyostatin

ACIE paper

Posted in Macrolides, Methodology, Total Synthesis | Leave a Comment »