Naturalproductman’s Blog

Hey, is that a natural product?!

Overbred intermediates

Posted by naturalproductman on July 24, 2013

Phil Baran and co-workers have reported in ACIE on the synthesis of steviol by using “overbred” intermediates, a term coined by Hoffman in 2009 referring to intermediates in a synthetic route that contain one or more C-C bond(s) that will break to get to the target product.

overbred

ACIE paper

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