Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for January, 2014

Peloruside vs. Taxol

Posted by naturalproductman on January 30, 2014

Michel Steinmetz and co-workers from Paul Scherrer Institut in Switzerland have reported in ACIE on a crystal structure of peloruside bound to beta-tubulin. Interestingly, peloruside and taxol bind to beta-tubulin differently.

taxol

ACIE paper

Posted in Cancer, Crystal Structure, Polyketides | Leave a Comment »

Gold catalyzed sigmatropic rearrangement

Posted by naturalproductman on January 20, 2014

Chepuri Ramana and colleague at CSIR have reported in Chem Comm on a gold catalyzed rearrangement of allenyl ethers.

rearrangement

Chem Comm paper

Posted in Allenes, Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

ASAP HSQC

Posted by naturalproductman on January 20, 2014

Burkhard Luy and co-workers at Karlsruher Institut für Technologie in Germany have reported in JACS on a quick HSQC NMR method.
HSQC
JACS paper

Posted in New Setups, New Types, NMR | 1 Comment »

Baulamycins

Posted by naturalproductman on January 17, 2014

David Sherman and co-workers found some new natural products with anti-biotic activities (IC50s ranging from low to high micromolar range) and reported this in JACS.
baulamycins

 

JACS paper

Posted in Antibiotics, Polyketides | Leave a Comment »

Lundurine synthesis

Posted by naturalproductman on January 17, 2014

Atsushi Nishida and co-workers from Chiba University have reported in Org Lett on the synthesis of lundurine.

lundurine

OL paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Job postings

Posted by naturalproductman on January 15, 2014

There are many places one can find postings for jobs. The back of the C&E News magazine in the classified usually has them.

 

http://www.wileyjobnetwork.com/

http://jobs.sciencecareers.org/

http://www.nature.com/naturejobs/science/

http://chemistryjobs.acs.org/jobs

Posted in Random | Leave a Comment »

Bischler–Napieralski-Type Cyclization

Posted by naturalproductman on January 13, 2014

Masaya Nakata and co-workers from Keio University have reported in Org Lett on a Bischler-Napieralski type reaction to form isoindolinones.

FC

OL paper

Posted in Bischler-Napieralski reaction, Cascade Reactions, Methodology, Named Reactions | 1 Comment »