Naturalproductman’s Blog

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Archive for April, 2014

Lansai B and Nocardioazines A and B syntheses

Posted by naturalproductman on April 28, 2014

Sarah Reisman and colleague have reported in ACIE on the synthesis of lansai B and nocardioazines A and B.

lansai B

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

5-exo-dig vs. 6-endo-dig cyclization

Posted by naturalproductman on April 25, 2014

Hideki Yorimitsu and co-workers from Kyoto University have reported in JACS on a palladium catalyzed cyclization of alkynols. The regioselectivity depends on the ligand used, Xantphos gives 6-membered rings and Xphos gives 5-membered rings.

 

JACS paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Hydroamination of 1,3-dienes

Posted by naturalproductman on April 25, 2014

Simon Meek and co-workers from UNC Chapel Hill have reported in JACS on an intermolecular hydroamination of 1,3-diene substates. Nice to see an intermolecular case, I think people usually  use platinum based catalysts for this – but my experience was not good using some platinum siloxy complex. User friendliness is always a good method.

hydroamination

JACS paper

Posted in Methodology, Rhodium, Transition Metal | Leave a Comment »

Asymmetric [2+2]

Posted by naturalproductman on April 25, 2014

Tehshik Yoon and co-workers published in Science on an enantioselective [2+2] reaction.

Science paper

Posted in Asymmetric, Cycloaddition, Light Mediated, Methodology, Pericyclic reactions, [2+2] | Leave a Comment »

Filiformin synthesis

Posted by naturalproductman on April 24, 2014

Varinder Aggarwal and co-workers from the University of Bristol have reported in ACIE on the synthesis of filiformin.

filiformin

ACIE paper

Posted in Total Synthesis | Leave a Comment »

Jiadifenolide synthesis

Posted by naturalproductman on April 24, 2014

Erik Sorensen and co-workers reported in ACIE on the synthesis of jiadifenolide.
jiadifenolide

ACIE paper

Posted in Total Synthesis | 1 Comment »

Lepenine synthesis

Posted by naturalproductman on April 24, 2014

Tohru Fukuyama and co-workers have reported in JACS on the synthesis of lepenine. I don’t know about you but I was checking the supporting information for any NMR spectra “too perfect” ;).

 

 

JACS paper

Posted in Alkaloids, Total Synthesis | 1 Comment »

Luciferin from earthworms

Posted by naturalproductman on April 18, 2014

Ilia Yampolsky and co-workers at the Russian Academy of Sciences have reported in ACIE on the isolation of luciferin from the luminous earthworm.

 

ACIE paper

Posted in Peptides, Polyenes | Leave a Comment »

Dimerization, electrochemically

Posted by naturalproductman on April 18, 2014

Phil Baran and co-workers reported in JACS on a synthesis of dixiamycin via electrochemical dimerization. I usually think of Kevin Moeller from Washington University in St. Louis when I see electrochemical reactions.

JACS paper

Posted in Dimer, Electrochemical, Indoles, Methodology, Total Synthesis | Leave a Comment »

Ingenol synthesis

Posted by naturalproductman on April 18, 2014

Phil Baran and co-workers reported in JACS on their synthesis of ingenol.

ingenol

JACS paper

Posted in Terpenoids, Total Synthesis | Leave a Comment »