Naturalproductman’s Blog

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5-exo-dig vs. 6-endo-dig cyclization

Posted by naturalproductman on April 25, 2014

Hideki Yorimitsu and co-workers from Kyoto University have reported in JACS on a palladium catalyzed cyclization of alkynols. The regioselectivity depends on the ligand used, Xantphos gives 6-membered rings and Xphos gives 5-membered rings.

 

JACS paper

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