Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for May, 2014

So they made the trophy target, now what?

Posted by naturalproductman on May 29, 2014

Did you ever wonder what happened to palau’amine after they synthesized it? Was it the end of the story there? Well they did publish in the Journal of Natural Products in 2012 on the target of palau’amine and it was an inhibitor for the human 20S proteasome. You may wonder what the proteasome does:  it just degrades proteins (broken down or not needed) through proteolysis. Is that exciting? Well that may be a subjective question. It may be like saying is Coke delicious?

 

JNP paper

 

Advertisements

Posted in Alkaloids, Chemical Biology, Elucidation of natural product bioactivity, Protein Targets | Leave a Comment »

Why chemistry matters…

Posted by naturalproductman on May 22, 2014

Here’s a great example that was highlighted in C&E News illustrating why it is good to know chemistry and why people who are careful chemists/scientists are so valuable. The El-Deiry lab at Penn State had patented a compound they discovered with anti-cancer activity. Then the Janda group in Scripps had synthesized the structure and found it did not have the biological activity that was reported, and then they received the compound from NCI and it did have activity. The original structural assignment was incorrect as shown by X-ray crystallography. Now there’s a big issue.

 

ACIE paper

Posted in Structural Reassignment, Total Synthesis | Leave a Comment »

Dihomoisofuran synthesis

Posted by naturalproductman on May 22, 2014

Jean-Marie Galano and co-workers at UMR in France have reported in ACIE on the synthesis and isolation of dihomoisofurans.

arachidonic acid

ACIE paper

Posted in Biomarkers, Fatty Acids, Total Synthesis | Leave a Comment »

Mandelalide A synthesis

Posted by naturalproductman on May 22, 2014

Tao Ye and co-workers at Hong Kong Polytechnic University have reported in ACIE on the synthesis of mandelalide.

mandelalide

ACIE paper

Posted in Macrolides, Total Synthesis | Leave a Comment »

Vaticanol A synthesis

Posted by naturalproductman on May 22, 2014

Scott Snyder and co-workers from Scripps (Florida) have reported in ACIE on the synthesis of vaticanol A.

vaticanol

ACIE paper

Posted in Aromatic, Methodology, Total Synthesis | Leave a Comment »

Logeracemin A

Posted by naturalproductman on May 21, 2014

Jian-Min Yue and co-workers from the Chinese Academy of Sciences have reported in JACS on the isolation of logeracemin A.

logeracemin A

JACS paper

Posted in Alkaloids, C2-Symmetric, Diseases, HIV | Leave a Comment »

Citrinalin and cyclopiamine syntheses

Posted by naturalproductman on May 19, 2014

Richmond Sarpong and co-workers reported in Nature on the syntheses of citrinalin and cyclopiamine.

 

Nature paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Academia vs. Industry

Posted by naturalproductman on May 17, 2014

Ever consider the pros and cons between academics and industry? Here’s a nice article from someone who had experience in both.

Plos article

Posted in Random | Leave a Comment »

Syn-elimination

Posted by naturalproductman on May 14, 2014

Cristina de Meo and co-workers from Southern Illinois University reported in Organic Letters on a thiosialoside elimination of a thiophenol group, occuring by syn-elimination.

syn

OL paper

Posted in Half-chair, Isotope effects, Mechanistic | 1 Comment »

Lepistine synthesis

Posted by naturalproductman on May 14, 2014

Tohru Fukuyama and co-workers published in Organic Letters on their synthesis of lepistine via a slick cascade reaction.

cascade

OL paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »