Naturalproductman’s Blog

Hey, is that a natural product?!

Why chemistry matters…

Posted by naturalproductman on May 22, 2014

Here’s a great example that was highlighted in C&E News illustrating why it is good to know chemistry and why people who are careful chemists/scientists are so valuable. The El-Deiry lab at Penn State had patented a compound they discovered with anti-cancer activity. Then the Janda group in Scripps had synthesized the structure and found it did not have the biological activity that was reported, and then they received the compound from NCI and it did have activity. The original structural assignment was incorrect as shown by X-ray crystallography. Now there’s a big issue.

 

ACIE paper

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