Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for August, 2014

Palladium catalyzed decarboxylative cycloaddition

Posted by naturalproductman on August 30, 2014

Yong Jian Zhang and co-workers at Shanghai Jiao Tong University have reported in ACIE on a palladium catalyzed decarboxylative cycloaddition.

palladium

ACIE paper

Advertisements

Posted in Cascade Reactions, Cycloaddition, Methodology, Palladium, Transition Metal | 1 Comment »

Palladium catalyzed decarboxylative cycloaddition

Posted by naturalproductman on August 30, 2014

Yong Jian Zhang and co-workers at Shanghai Jiao Tong University have reported in ACIE on a palladium catalyzed decarboxylative cycloaddition.

palladium

ACIE paper

Posted in Cascade Reactions, Cycloaddition, Methodology, Palladium, Transition Metal | Leave a Comment »

Varioxepine A

Posted by naturalproductman on August 28, 2014

Bin-Gui Wang and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of an interesting oxepine containing alkaloid.

oxepine

OL paper

Posted in Alkaloids, Oxepines, Spirocycles | Leave a Comment »

C-C bond cleavage with titanium

Posted by naturalproductman on August 28, 2014

Zhaomin Hou and co-workers at RIKEN (Saitama, JP) have reported in Nature on a titanium hydride complex that cleaves carbon-carbon bonds.

 

Nature paper

Posted in C-C Bond Breaking, Methodology, Titanium, Transition Metal | Leave a Comment »

Breaking benzene

Posted by naturalproductman on August 28, 2014

Petr Beier and co-workers from the Academy of the Sciences of the Czech Republic have reported in JOC on an interesting reaction involving hydrogen peroxide, and an SF5-phenol to afford a muconolactone derivative.

BV
JOC paper

Posted in Cascade Reactions, Mechanistic, Methodology, Named Reactions | Leave a Comment »

Stereospecific Aggarwal boronate rearrangement

Posted by naturalproductman on August 28, 2014

Chris Senanayake and co-workers from Boehringer Ingelheim have reported in Organic Letters on an interesting transformation involving a lithiated carbamate and a boronate.

boron

OL paper

Posted in Cascade Reactions, Methodology, Named Reactions | Leave a Comment »

CO2 as a protecting group?

Posted by naturalproductman on August 20, 2014

Arjan Kleij and co-workers from ICIQ in Spain have reported in ACIE on the use of carbon dioxide as a protecting group for cis-diols arising from epoxides using an iron or aluminum aminotriphenolate complex to make the carbonate from the epoxide.

carbon dioxide

ACIE paper

Posted in Methodology, New Types, Protecting Groups | 2 Comments »

Cholesterol analog to probe SHH protein

Posted by naturalproductman on August 20, 2014

Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.

cholesterol

Chemical Science paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Sinulariaoid A

Posted by naturalproductman on August 20, 2014

Cui-Xian Zhang and co-workers from Guangzhou University have reported in Tetrahedron on a poly-sulfur lactone compound.

sulfur

Tetrahedron paper

Posted in Apoptosis, Cancer, Lactones, Polythio Compounds | Leave a Comment »

Cyclobutenone ring expansion

Posted by naturalproductman on August 20, 2014

Guangbin Dong and colleague at UT Austin have reported in ACIE on the synthesis of cycloinumakiol through a rhodium catalyzed cascade reaction that forms the tetracyclic ring structure of the compound.

C-C

ACIE paper

Posted in Methodology, One pot, Rhodium, Ring expansion, Ring forming, Ring Opening, Total Synthesis, Transition Metal | Leave a Comment »