Intermolecular hydroamination

Stephen Buchwald and colleague have reported in JACS on an asymmetric intermolecular hydroamination reaction. I personally have tried an intermolecular hydroamination using a platinum catalyst, and it failed. This protocol is hopefully a good alternative.

JACS paper

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Leiodermatolide synthesis

Furstner and colleagues have reported in JACS on the synthesis of leiodermatolide.

JACS paper

Synthesis of 6-Deoxypladienolide D, which binds to SF3B1

Gregg Keaney and co-workers at H3 Biomedicine have reported in Org Lett on the synthesis of 6-deoxypladienolide D.

OL paper

Paracaseolide A synthesis

Goverdhan Mehta (University of Hyderabad) and co-workers at IIT Hyderabad have reported in Tetrahedron on the synthesis of paracaseolide A.

Tetrahedron paper

Amdigenols E and G

Toshiyasu Inuzuka and co-workers from Gifu University have reported in Tetrahedron Letters on the isolation of amdigenols E and G from dinoflagellates, and they had activity against N-type Ca2+ channel opening.

TL paper

Axinellamines A and B

When I saw the abstract figure, I wasn’t surprised to see that this paper came from Phil Baran’s group.

JACS paper

Strained alkynes are in

Rick Danheiser and colleague have reported in JACS on the synthesis of an aza-cyclohexyne to do the chemistries that other people have been doing with benzynes.

JACS paper

Triphenylphosphine (oxide) removal solved!

You might remember an older post on something about the difficulty in removing triphenylphosphine or triphenylphosphine oxide removal. But first, how about a brief background: why would someone use triphenylphosphine in the first place? Well I can think of several reasons:

(1) Baylis-Hilman reaction

(2) Any metal cross coupling reaction using palladium tetrakis triphenylphosphine catalyst

(3) Mitsunobu reaction

So my particular problem was using the palladium tetrakis reagent to remove an Alloc protecting group.

You can see the details of the solution in page S-104 in supporting information file. But basically in a nutshell, instead of using tetrakis, I used Pd(DBA)2 and trimethylphosphine (PMe3) as the ligand, which evaporates at 38 degrees celsius.

Haouamine B pentaacetate synthesis

Hidetoshi Tokuyama and co-workers from Tohoku University have reported in ACIE on the synthesis of haouamine B pentaacetate.

ACIE paper

Spinosyn A, chemoenzymatically

Hung-Wen Liu and co-workers from UT Austin have reported in ACIE on the chemoenzymatic synthesis of spinosyn A.

 

ACIE paper