Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for January, 2015

Monamphilectines B and C

Posted by naturalproductman on January 18, 2015

Abimael Rodriguez and co-workers from the University of Puerto Rico have reported in Tetrahedron on the isolation of monamphilectines B and C.

emphilectane

Tetrahedron paper

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Posted in Alkaloids, Cancer | Leave a Comment »

How to make an endoperoxide

Posted by naturalproductman on January 18, 2015

Yikang Wu and colleague at SIOC have reported in Organic Letters on an interesting epoxy-olefin rearrangement to access endoperoxides.

endoperoxide

OL paper

Posted in Cascade Reactions, Methodology, Peroxides | Leave a Comment »

Looks like a hydroacylation

Posted by naturalproductman on January 18, 2015

Aleander Radosevich and co-workers from Penn State have reported in JACS on a phosphetane catalyzed deoxygenative condensation between an alpha-ketoester and a carboxylic acid.
reduction

JACS paper

Posted in Methodology, Phosphorous | Leave a Comment »

Posted by naturalproductman on January 18, 2015

Masahiro Terada and co-workers from Tohoku University have reported in JACS on a kinetic resolution approach to accessing chiral amino-alcohols using a chiral phosphoric acid to form an acetal.

phosphoric

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology | Leave a Comment »

Looks like bromophakellin

Posted by naturalproductman on January 17, 2015

Michael Groll and co-workers at Michigan State have reported in ACIE on the target of of some indolo-phakellin natural products (proteasome).

phakellin

ACIE paper

Posted in Alkaloids, Chemical Biology, Indoles | Leave a Comment »

Trioxacarcin DC-45-A2 synthesis

Posted by naturalproductman on January 17, 2015

KC Nicolaou and co-workers have reported in ACIE on the synthesis of trioxacarcin DC-45-A2. polyketide ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Jahanyne

Posted by naturalproductman on January 17, 2015

Kiyotake Suenaga and co-workers from Keio University have reported in Organic Letters on the isolation of jahanyne.

lipopeptide
OL paper

Posted in Apoptosis, Peptides | Leave a Comment »

Aglaiastatin synthesis

Posted by naturalproductman on January 17, 2015

John Porco and co-workers have reported in JACS on the synthesis of aglaiastatin.
aglaiastatin
JACS paper

Posted in Asymmetric, Methodology, Polyketides, Total Synthesis | Leave a Comment »

Desymmetrization via hydramination

Posted by naturalproductman on January 17, 2015

Aaron Sadow and co-workers at Iowa State have reported in JACS on a desymmetrization hydroamination reaction using a zirconium catalyst and the result is different depending on whether the reaction is dilute or concentrated.

concentrated

JACS paper

Posted in Desymmetrization, Methodology, Transition Metal, Zirconium | Leave a Comment »

trans-Clerodane natural product synthesis

Posted by naturalproductman on January 17, 2015

Larry Overman and co-workers have reported in JACS on the synthesis of trans-clerodane natural products.

clerodane

JACS paper

Posted in Asymmetric, Methodology, Terpenoids, Total Synthesis | 1 Comment »