At first look of the abstract figure I thought this was an Overman rearrangement paper but no, trichloroacetimidates are also good leaving groups for Sn2 prime reactions.
Archive for May, 2015
Sn2 prime with trichloroacetimidates
Posted by naturalproductman on May 28, 2015
Posted in Cascade Reactions, Methodology, Ring forming, Sn2 prime | Leave a Comment »
Hofmann–Löffler-Freytag Reaction
Posted by naturalproductman on May 28, 2015
Kilian Muñiz and colleague at ICIQ have reported in ACIE on an iodine catalyzed Hofmann–Löffler-Freytag reaction.
Posted in Hofmann–Löffler–Freytag-type, Methodology, Named Reactions | Leave a Comment »
Synthesis of Paclitaxel exploiting new ways
Posted by naturalproductman on May 28, 2015
Noritaka Chida and co-workers from Keio University have reported in Organic Letters on a radical cyclization approach toward taxol.
They access the oxetane ring via intramolecular mesylate displacement.
Posted in Cascade Reactions, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »
Sigillin A
Posted by naturalproductman on May 13, 2015
Stefan Schulz and co-workers at TU Braunschweig have reported in ACIE on the isolation of a polychlorinated natural product from the snow flea.
There’s a typo in the description of the article: ” in which α-vinylation of a lactone and ring-closing metathesis are they key steps.” should be “are the key steps.”
ACIE paper
Posted in Halogenated | Leave a Comment »
Towards halichondrins
Posted by naturalproductman on May 12, 2015
I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.
Posted in Chromium, cross coupling, Methodology, Named Reactions, Nickel, Polyketides, Total Synthesis | Leave a Comment »
HIV integrase inhibitor synthesis
Posted by naturalproductman on May 12, 2015
Chris Senanayake and co-workers from Boehringer-Ingelheim have reported in ACIE on the synthesis of
Posted in Diseases, HIV, Total Synthesis | Leave a Comment »
Sarain A synthesis
Posted by naturalproductman on May 12, 2015
Tohru Fukuyama and co-workers at Nagoya University and the University of Tokyo have reported in ACIE on a formal synthesis of sarain A.
Posted in Alkaloids, Total Synthesis | Leave a Comment »