Sn2 prime with trichloroacetimidates

At first look of the abstract figure I thought this was an Overman rearrangement paper but no, trichloroacetimidates are also good leaving groups for Sn2 prime reactions.

ACIE paper

Syn-1,3-carbonate access

Matthew Gaunt and colleague at the University of Cambridge have reported in ACIE on a method for the synthesis of syn-1,3-carbonates.

ACIE paper

Hofmann–Löffler-Freytag Reaction

Kilian Muñiz and colleague at ICIQ have reported in ACIE on an iodine catalyzed Hofmann–Löffler-Freytag reaction.

ACIE paper

Sufur ylide chemistry – intramolecular cyclopropanation

Nuno Maulide and co-workers from the University of Vienna have reported in JOC on an intramolecular cyclopropanation from a sulfur slide precursor and what follows is a nice mechanistic investigation.

JOC paper

Synthesis of Paclitaxel exploiting new ways

Noritaka Chida and co-workers from Keio University have reported in Organic Letters on a radical cyclization approach toward taxol.

OL paper

They access the oxetane ring via intramolecular mesylate displacement.

OL paper2

Brevisin via epoxide ring opening

Timothy Jamison and co-workers have reported in JACS on their formal synthesis of brevisin.

JACS paper

Sigillin A

Stefan Schulz and co-workers at TU Braunschweig have reported in ACIE on the isolation of a polychlorinated natural product from the snow flea.

There’s a typo in the description of the article: ” in which α-vinylation of a lactone and ring-closing metathesis are they key steps.” should be “are the key steps.”

ACIE paper

Towards halichondrins

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

JACS paper

JACS paper 2

HIV integrase inhibitor synthesis

Chris Senanayake and co-workers from Boehringer-Ingelheim have reported in ACIE on the synthesis of

ACIE paper

Sarain A synthesis

Tohru Fukuyama and co-workers at Nagoya University and the University of Tokyo have reported in ACIE on a formal synthesis of sarain A.

ACIE paper