Naturalproductman’s Blog

Hey, is that a natural product?!

Asperchalasine A

Posted by naturalproductman on September 3, 2015

Here’s a natural product isolation paper that was published in ACIE. Yonghui Zhang and co-workers report on the isolation of asperchalasine A, which induced G-1 phase cell cycle arrest by reducing the expression of cyclin A, CDK2, and CDK6 in cancer cells but not in normal cells at 20 micromolar (pretty high concentration so not so potent in my opinion).

asperchalasine A

ACIE paper

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