Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for October, 2015

MPC1001B synthesis

Posted by naturalproductman on October 23, 2015

Hidetoshi Tokuyama and co-workers from Tohoku University have reported in ACIE on the synthesis of MPC1001B.

polythio

ACIE paper

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Posted in Methodology, Polythio Compounds, Total Synthesis | Leave a Comment »

Crotophorbolone synthesis

Posted by naturalproductman on October 23, 2015

Masayuki Inouye and co-workers have reported in ACIE on the synthesis of crotophorbolone.

radical

ACIE paper

Posted in Cascade Reactions, Methodology, Radical Chemistry, Seven-Membered Rings, Terpenoids, Total Synthesis | Leave a Comment »

Steroid C12-hydroxylation published in JACS

Posted by naturalproductman on October 22, 2015

Phil Baran and co-workers reported in JACS on a copper catalyzed C12-hydroxylation reaction.
C12
 

 

JACS paper

Posted in C-H activation, Copper, Methodology, Steroids, Transition Metal | Leave a Comment »

LmbF is a PLP-enzyme

Posted by naturalproductman on October 21, 2015

Jiri Janata and co-workers from ASCR in the Czech Republic have reported in Chemical Science on the identification of the enzyme, LmbF, in the biosynthesis of lincomycin.

lincomycin

Chemical Science paper

Posted in Alkaloids, Biosynthesis, Chemical Biology, Tetrahydropyrans | Leave a Comment »

An allene and cyclobutanone walk into a bar…

Posted by naturalproductman on October 21, 2015

Guangbin Dong and colleague have reported in JACS on an intramolecular coupling between cyclobutanones and allenes.

cyclobutanone

JACS paper

Posted in Cascade Reactions, Methodology, Rhodium, Ring forming, Ring Opening, Transition Metal | Leave a Comment »

Hydroamidation of olefins

Posted by naturalproductman on October 21, 2015

Robert Knowles and co-workers at Princeton have reported in JACS on a hydroamidation of olefins using an iridium catalyst.

hydroamidation

JACS paper

Posted in Iron, Light Mediated, Methodology, Transition Metal | Leave a Comment »

Isochizogamine synthesis

Posted by naturalproductman on October 21, 2015

Jieping Zhu and co-workers reported in ACIE on the synthesis of isochizogamine.

isochizogamine

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Got wood?

Posted by naturalproductman on October 21, 2015

Till Opatz and co-workers at Institut für Organische Chemie reported in ACIE on the synthesis of from compounds from wood – methyl gallate, ferulic acid, and methanol.
wood
ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Leuconodine F synthesis

Posted by naturalproductman on October 21, 2015

Jieping Zhu and co-workers reported in ACIE on the synthesis of leuconodine F.

alkaloid

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Using carbon dating to show that tramadol is NOT a natural product afterall

Posted by naturalproductman on October 21, 2015

Remember that debate whether tramadol was really a natural product or not? Michael Spiteller and co-workers at TU Dortmund used accelerator mass spectrometry to analyze the isotopes of carbon found in tramadol found in the soil to show that tramadol is NOT a natural product. This is all based on the fact that natural organic compounds that are biosynthesized in living organisms contain amounts of 14C-radioisotope close to that of the environment.
tramadol
ACIE paper

Posted in Mass Spectrometry, Unnatural Products | Leave a Comment »