Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for October, 2015

Unciaphenol – Bergman cyclization product of uncialamycin

Posted by naturalproductman on October 16, 2015

Raymond Anderson and co-workers at the University of British Columbia report in Organic Letters on unciaphenol, which has anti-HIV activity.

unciaphenol

OL paper

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Posted in Alkynes, Cascade Reactions, Diseases, HIV, Named Reactions, Polyketides | Leave a Comment »

Fastigiatine synthesis

Posted by naturalproductman on October 16, 2015

Scott Rychnovsky and co-workers have reported in Chemical Science on the synthesis of fastigiatine.

fastigiatine

Chemical Science paper

Posted in Alkaloids, Cascade Reactions, Total Synthesis | Leave a Comment »

From gene clusters to biosynthesis of natural products

Posted by naturalproductman on October 16, 2015

Leadlay (University of Cambridge) and Sun (Wuhan University) and co-workers have reported in Chemical Science on thiotetronate biosynthesis.

gene

Chemical Science paper

Posted in Biosynthesis, Mechanistic, Thiotetronate | Leave a Comment »

Diels-Alder back to back

Posted by naturalproductman on October 16, 2015

Xuegong She and co-workers from Lanzhou University have reported in Chemical Communications on a domino Diels-Alder transformation to form a polycyclic scaffold.

Diels-Alder

Chemical Communications paper

Posted in Cascade Reactions, Diels-Alder, Methodology, Named Reactions | Leave a Comment »

[6+4] vs [4+2]

Posted by naturalproductman on October 16, 2015

Kendall Houk and co-workers have reported in JACS on a biosynthetic study of heronamide A using DFT calculations to study the [6+4] cycloaddition.

6+4

JACS paper

Posted in Biosynthesis, Cycloaddition, DFT | Leave a Comment »

Atisane-type diterpenoids

Posted by naturalproductman on October 16, 2015

Bo Liu and co-workers at Sichuan University have reported in JACS on the synthesis of atisane-type diterpenoids.

atisane

JACS paper

Posted in Diels-Alder, Diterpenoids, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Marthiapeptide synthesis

Posted by naturalproductman on October 15, 2015

Shelli McAlpine and co-workers at the University of New South Wales have reported in Organic Letters on the synthesis of marthiapeptide.

peptide

OL paper

Posted in Peptides, Total Synthesis | Leave a Comment »

Coibamide A synthesis

Posted by naturalproductman on October 15, 2015

Wu Su and co-workers from the Chinese Academy of Sciences have reported in JACS on the synthesis of coibamide A.

peptide

JACS paper

Posted in Macrocycles, Peptides, Structural Reassignment, Total Synthesis | Leave a Comment »

Paracaseolide A synthesis

Posted by naturalproductman on October 13, 2015

Thomas Hoye and colleague at the University of Minnesota have reported in Nature Chemistry on a Diels-Alder reaction to access paracaseolide.

Nature Chemistry paper

Posted in Biomimetic, Cascade Reactions, Diels-Alder, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Marmycin A synthesis

Posted by naturalproductman on October 13, 2015

Raphael Rodriguez and co-workers at CNRS UMR have reported in Nature Chemistry on the synthesis of marmycin A.

Nature Chemistry paper

Posted in Chemical Biology, Polyketides, Total Synthesis | Leave a Comment »