Naturalproductman’s Blog

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Alkyne hydrothiolation with Wilkinson’s catalyst

Posted by naturalproductman on January 27, 2016

Jennifer Love and co-workers from the University of British Columbia reported in Organic Letters on the use of Wilkinson’s catalyst to perform a hydrothiolation reaction across an alkyne to synthesize K777, a cysteine protease inhibitor.

 

OL paper

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