Naturalproductman’s Blog

Hey, is that a natural product?!

Precolibactin synthesis/structural revision

Posted by naturalproductman on March 31, 2016

Seth Herzon and co-workers from Yale have reported in JACS on the synthesis of precolibactin. It’s another example of why total synthesis is important. But another interesting aspect about this natural product is that previous efforts used bioinformatics approaches to propose the thiazoline-thiazole chain – when in fact the natural product has a terminal cysteine appended where this thiazoline-thiazole chain was proposed to exist.


JACS paper

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