Naturalproductman’s Blog

Hey, is that a natural product?!

Olefin difluorination

Posted by naturalproductman on April 5, 2016

Eric Jacobsen and co-workers reported in JACS on a difluorination of an olefin. They accomplished this transformation by using mCPBA (1.1 equivalent), HF-pyridine (100 equivalents of HF), and an aryl iodide derivative (catalyst).

 

JACS paper

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

 
%d bloggers like this: