Naturalproductman’s Blog

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Olefin difluorinations are in

Posted by naturalproductman on April 7, 2016

Ryan Gilmour and colleague at Westfal̈ische Wilhelms-Universitaẗ Münster have reported in JACS on a difluorination of an olefin using p-iodotoluene, selectfluor, and various sources of amine-HF including TREAT-HF (triethylamine trihydrofluoride). They also try to expand on the transformation by making it asymmetric using a C2-symmetric chiral aryl iodide.

 

JACS paper

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